Transplantation immunity

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Quantitation of Transplantation Immunity

A technique for in vivo quantitation of transplantation immunity has been presented. Known numbers of H(3)-thymidine-labeled lymphoid cells were injected intravenously into isologous or homologous recipients. The total radioactivity in host spleens was counted at different time intervals. The rate of isotope disappearance from the spleen was exponential to 0.5 per cent of the dose or less. In i...

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Transplantation immunity in bone homografting.

The knowledge that homografts of many tissues have a limited period of survival, and the revival of the theory of tissue immunity (Gibson and Medawar 1943, Medawar 1944, 1945) makes it of interest to know how bone homografts compare with other tissues in this respect. Since 1878 homografts ofbone have been known to be clinically effective (Macewen 1912), and the introduction of the bone bank (I...

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Cellular Immunoabsorbents in Transplantation Immunity

Mouse lymphoid cells, sensitized against tumor allografts, can be deprived of the immunoreactive cells by in vitro absorption with specific fibroblast monolayers. Populations of lymphocytes so depleted are less effective in retarding tumor growth in vivo and in lysing tumor cells in vitro. Moreover, the adsorbed immunoreactive cells can be recovered specifically and are subsequently efficient i...

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Passive Transfer of Transplantation Immunity

Passive transfer of transplantation immunity was accomplished in inbred guinea pigs with tritiated thymidine-labeled lymphoid cells sensitized to homologous tissues. Autoradiographs of the homologous skin graft sites disclosed the presence of relatively few or no labeled cells at the site of rejection. Passive transfer of transplantation immunity was also accomplished with sensitized lymphoid c...

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Polyomavirus BK-specific immunity after kidney transplantation.

Failure to mount or maintain a protective immune response may influence the development of polyomavirus BK (BKV)-associated nephropathy (PVAN). However, limited data are so far available on BKV-specific immunity after kidney transplantation. BKV-specific cellular immune response was retrospectively analyzed in kidney recipients with or without BKV infection/reactivation by measuring the frequen...

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ژورنال

عنوان ژورنال: Arthritis & Rheumatism

سال: 1964

ISSN: 0004-3591,1529-0131

DOI: 10.1002/art.1780070112